This project belongs to the field of inorganic non-metallic composite materials in the discipline of materials science. It is a research on new nanomaterials synthesis methods and biological effects for biomedical applications, integrating multiple professional directions such as materials, chemistry, biology, and medicine. The project is oriented towards the needs of systematic drug delivery for tumor treatment, based on materials science, chemistry, and biology, to design intelligent nano-systems with multi-level and multifunctional capabilities. It provides new ideas for the design and construction of multifunctional nanocarriers that are targeted at tumors and responsive to the tumor microenvironment. Preliminary conceptual validation has also been conducted. The project includes two parts: one is the controllable preparation of organic-inorganic heterojunction nanocomposite structures and their surface functionalization modification methods, as well as research on drug delivery carriers for tumor cell targeting and pH value responsiveness; the other part is aimed at tumor-selective drug release. High molecular weight micelle nanostructures that can sensitively respond to weak signal stimuli in the tumor microenvironment; study new mechanisms for rapid intelligent drug release. This project lists 8 representative achievements published in internationally renowned academic journals such as Advanced Materials, Small, Chemical Communications, J Colloid Interface Sci, and Langmuir. The total impact factor of the articles is 60.07, with the highest single article impact factor being 21.95; the total number of citations is 603, including 55 self-citations; the highest number of citations per article is 158. Three authorized invention patents have been obtained. The research paper has been positively cited and described in detail by renowned international review journals such as Chemical Reviews, Chemical Society Reviews, and Progress in Polymer Science. It has attracted widespread attention from peers both domestically and internationally and has played an important role in promoting the development of this field. The main scientific research content includes: using a combined process of heterogeneous polymerization and sol-gel reaction to synthesize organic-inorganic nanomultilayered and heterojunction structures. It investigates the facile and efficient controllable assembly behavior of various building blocks, the anisotropy of the assembled bodies, and focuses on the ordered assembly of multifunctional components in carriers for targeted and responsive delivery of nanomedicines. Additionally, it addresses the need to avoid interference between functions by establishing an internationally advanced innovative preparation method for heterojunction nanocomposite structures. As well as modifying the functional groups of relatively independent surfaces in composite structures, and targeting molecule conjugation and drug molecule conjugation, this can achieve tumor cell targeting and pH environment responsiveness for controlled drug release in a relatively independent yet organically integrated manner. Main scientific research content two: In response to the problems of poor efficacy and high side effects that exist during conventional chemotherapy treatment, intelligent nano-drug carriers have emerged. They can solve the main problems of conventional chemotherapy drugs by sensing changes in environmental information at the diseased site; however, traditional smart carriers still have some shortcomings: such as pH and temperature sensitive nano-drug carriers designed for the weak acidic environment and slightly elevated temperature of tumors are limited in their application process. This is mainly because the differences between tumors and normal tissues in pH and temperature are too small, and traditional smart nano-carriers can only mediate drug release through micro-tuning of the nanostructure (such as swelling). Therefore, it is difficult to achieve tumor-specific differential release. This project is based on the design of polymer micelles' structure, size, and surface chemical groups, constructing intelligent nanomedicine carriers that respond to the tumor microenvironment. It develops carriers that can sensitively respond to weak signal stimuli from the tumor microenvironment and perform rapid intelligent drug release, addressing core issues such as how to overcome various physiological barriers in the body and enhance the tumor targeting of drugs. It provides new methods and mechanisms for potentially achieving targeted, timed, and quantitative control of drug release.