Antimicrobial polymer materials are developing rapidly and represent an effective means to prevent bacterial growth and inhibit the emergence of multidrug resistance. Antimicrobial polymer materials based on polymer vesicles as carriers can achieve effective antimicrobial action through mechanisms such as metal ion antibacterial, organic antibacterial agents, natural antibacterial agents, etc., and have broad application value. Among them, antimicrobial polymer materials containing natural antibacterial agents (antimicrobial peptides) have a promising application prospect. Antimicrobial peptides kill bacteria by disrupting their biofilm, which is a physical action that can effectively avoid the development of bacterial multidrug resistance. In today's era of antibiotic overuse, antimicrobial peptides, as a new class of antimicrobial drugs, have good development prospects. The team has designed an antimicrobial peptide vesicle that has excellent antimicrobial effects, with an MIC value reaching 16ug/mL. At the same time, the polymer ends were modified with folic acid to encapsulate anticancer drugs. This allows it to target cancer cells, achieving both anti-cancer and antibacterial effects during treatment. This enables the inherent antimicrobial properties of the drug carrier to effectively prevent inflammation at the site of cancerous lesions, making this 'antibacterial-coated' drug carrier a promising prospect in cancer therapy. A copolymer based on natural high molecular weight chitosan and antimicrobial peptides has been designed and synthesized, resulting in antimicrobial peptide vesicles with good biocompatibility. The MIC (Minimal Inhibitory Concentration) of the antimicrobial peptide vesicles is 16μg/mL, which is superior to that of the same component's antimicrobial peptide segments. Furthermore, the H50 (Half-maximal Hemolysis Concentration) of the antimicrobial peptide vesicles is 700mg/dL, while the H50 of the same component's antimicrobial peptide is 110mg/mL, indicating that the antimicrobial peptide vesicles can significantly enhance the biocompatibility of antimicrobial peptides. The overall low cytotoxicity of the antimicrobial peptide vesicles High antimicrobial performance has great application prospects both in the human body and in animals.