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Glass-basednanohydroxyapatitebioceramicanditspreparationmethod

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Registration number:G20250606

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Key words: multiphase composite Nano hydroxyapatite

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Publisher:管理人员

Release time:2025-08-09 08:56:31.0

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Name of achievement: Glass-basednanohydroxyapatitebioceramicanditspreparationmethod
Result registration number: G20250606 Subject classification:
Green classification: Item keywords: multiphase composite  Nano hydroxyapatite      
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Tongji University

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Mode of cooperation: Outcome Information:
Countries/regions: China Intellectual property rights:
Introduction: Click to view
Human organs and tissues often suffer damage or loss of function due to inflammation, injury, aging, tumors, or congenital malformations. To replace, repair, or reconstruct these organs or tissues, a surge of artificial bones and joints made from alloys, high-molecular-weight materials, and bioceramics has emerged. However, these biomaterials are difficult to process into components for the organs or tissues to be repaired or replaced in a timely manner according to the shape of the defect during surgical procedures, limiting their application. The purpose of this invention is to provide a bone adhesive with high biological activity and mechanical strength, as well as the ability to release calcium ions, which have an inhibitory effect on cancer cells, also known as bio-cement. It is a multiphase composite composed of a phosphate glass phase and a nanohydroxyapatite crystal phase. The phosphate glass phase endows the bio-cement with excellent biocompatibility and biological activity. When mixed with a diluent, it exhibits the property of gradually increasing viscosity. The resulting mixture can eventually cure on its own and bond bone components together. During mixing, the product of the curing reaction, ammonium phosphate hydrate, is acted upon by human physiological simulation fluid to produce neo-formed hydroxyapatite, which induces the formation and growth of new bone.
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