Diabetic vascular disease is a major cause of disability and death in patients. Currently, the morphological pathology data on diabetic peripheral vascular disease are not yet complete, and the pathogenesis has not been fully elucidated, with treatment methods also needing improvement. This project utilizes angiography to directly observe the morphological characteristics of diabetic peripheral vascular disease, providing a morphological basis for understanding this condition. At the same time, interventional therapy is implemented for some patients to improve blood supply to their peripheral limbs, thereby preserving limbs as much as possible. The research also employs simple and feasible methods (venous occlusion test to assess endothelial tPA and NO reserve release function, and ultrasound to detect vascular dilation function) to judge the endothelium function of blood vessels, which helps understand the extent and prognosis of vascular lesions. In addition, molecular biology research on diabetic vascular disease using gene chips and immunohistochemistry techniques is conducted. This study provides a theoretical basis for elucidating the pathogenesis of diabetic vascular complications in clinical practice. By utilizing this technology, gene expression differences and related protein expressions were observed in peripheral blood vessels of diabetic mice treated with statins, aiming to elucidate the molecular changes in the treatment of diabetic peripheral vascular disease using statins based on circulatory medical evidence. This aims to demonstrate the rationality of using statins in diabetic patients and the effectiveness of different types of statins, providing a basis for the prevention and treatment of vascular complications in diabetic patients. The research explores the status of diabetic peripheral vascular disease at different levels, which helps to understand the patterns of onset of diabetic peripheral vascular disease and provides reasonable methods and theoretical bases for diagnosis and treatment. Experts have discussed that the research has reached the advanced level domestically.