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EstablishmentandApplicationofQuantitativeEvaluationMethodsfortheTreatmentofNeurologicalDiseaseswithIntegratedTraditionalChineseandWesternMedicine

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Registration number:G20251380

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Key words: Neurological Diseases Quantitative Evaluation Integrated Traditional Chinese and Western Medicine

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Publisher:管理人员

Release time:2025-08-09 09:20:48.0

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Name of achievement: EstablishmentandApplicationofQuantitativeEvaluationMethodsfortheTreatmentofNeurologicalDiseaseswithIntegratedTraditionalChineseandWesternMedicine
Result registration number: G20251380 Subject classification:
Green classification: Item keywords: Neurological Diseases   Quantitative Evaluation  Integrated Traditional Chinese and Western Medicine    
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Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital

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Mode of cooperation: Outcome Information:
Countries/regions: Shanghai Intellectual property rights: Other
Introduction: Click to view
Research Background: Currently, in the evaluation of the severity or efficacy of neurological diseases, both domestically and internationally, scales are commonly used for patient self-assessment or physician assessment. The objective quantification of evaluations by evaluators with different experience levels or patients' self-assessments is poor, especially when it comes to evaluating the efficacy of traditional Chinese medicine (TCM) or integrated TCM and Western medicine treatments for neuropsychiatric diseases. The efficacy indicators obtained from such evaluations are not easily recognized by peers in Western medicine both domestically and internationally. Therefore, providing an objectively quantitative evaluation method recognized by medical professionals at home and abroad is an urgent issue that clinical doctors, especially those practicing integrated TCM and Western medicine, need to address. Main Research Content: Utilizing accelerometer data recorded by actigraphs to measure human activity levels, a specific fractal analysis method is applied to evolve into a power-law exponent analytical approach. Display the parameters reflecting various disease degrees contained in physical activity to objectively evaluate the severity of Parkinson's disease, Parkinson's disease sleep disorder, Parkinson's disease non-motor symptoms, limb movement disorders due to cerebral infarction, behavioral abnormalities in vascular dementia, and itching degree. Key innovation points: Adjust the analysis method according to different diseases, 'treating based on disease differentiation', develop different confusion analysis methods for different diseases, use specific methods to analyze parameters obtained from body activity data recorded by accelerometers to evaluate the efficacy of integrated traditional Chinese and Western medicine treatment for neurological and psychiatric diseases. Compared with commonly used scales and methods in Western medicine at home and abroad, it has strong objectivity and quantification, high sensitivity and specificity in evaluating the efficacy of drugs for neurological diseases related to physical activity, and enhances the credibility of the efficacy of traditional Chinese medicine. Moreover, it is simple to operate and easy to promote. Application promotion and patents: Since the introduction of this research method in 2007, it was objectively quantified and evaluated for the severity of depression in 14 patients at Osaka University Graduate School of Medicine (see attached paper); in 2008, a study on the efficacy of transcranial magnetic stimulation for Parkinson's disease motor disorders was conducted in 14 patients at the Affiliated Hospital of Tokyo University Medical School, achieving good results (see attached paper); in 2008, it was used at the Osaka Bioscience Institute for research on human behavioral characteristics and mouse behavioral characteristics (see attached paper); in 2012, the Harvard Medical School in the United States used the power-type auto-correlation index method to study 14 patients with seasonal affective disorder and 12 healthy controls, achieving good results (see attached paper). This power-type auto-correlation index method has been used by the research team led by Fuzhong Li, Chief Scientist at the Oregon Research Institute in the United States, to evaluate the efficacy of Tai Chi for Parkinson's disease balance disorders (the paper has not yet been published, see the application proof attached); Professor Santiago Pérez Lloret from Toulouse University in France used this method to evaluate the efficacy of Vedic medicine in treating motor disorders of Parkinson's disease (evaluated about 80 patients, the paper is under publication, see the application proof attached); The Acupuncture and Moxibustion College of Kansai Medical University in Osaka, Japan, used it to evaluate the efficacy of acupuncture treatment for circadian rhythm disorders in shift workers (published, see the application proof attached). In China, Professor Cai Dingfang from the Department of Traditional Chinese Medicine at Zhongshan Hospital Affiliated to Fudan University evaluated the efficacy of traditional Chinese medicine in treating Parkinson's disease. The Department of Otolaryngology at Guangdong Provincial People's Hospital evaluates the degree of dizziness, the Department of Respiratory Medicine at the Second Affiliated Hospital of Ningxia Medical University uses traditional Chinese medicine to treat nocturnal sleep disorders in patients with emphysema, and Professor Zhang Huimin from the Department of Dermatology at Shuguang Hospital evaluates the efficacy of skin itching treatment (see attached papers and application certificates). Since its publication, this method has been used to evaluate more than 800 patients with various diseases from home and abroad. It has applied for one national patent, published 28 papers, including 14 domestic core journals, 13 international English papers, of which 9 are included in SCI, co-authored an English monograph, and contributed to a Japanese paper.
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