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EstablishmentandApplicationoftheComprehensiveTraditionalChineseMedicineDiagnosisandTreatmentSystemforStagesofChronicHeartFailure

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Registration number:G20251371

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Key words: Comprehensive Prevention and Treatment Treating in Stages Chronic Heart Failure

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Publisher:管理人员

Release time:2025-08-09 09:20:36.0

  • Essential information
Name of achievement: EstablishmentandApplicationoftheComprehensiveTraditionalChineseMedicineDiagnosisandTreatmentSystemforStagesofChronicHeartFailure
Result registration number: G20251371 Subject classification:
Green classification: Item keywords: Comprehensive Prevention and Treatment  Treating in Stages   Chronic Heart Failure    
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Shanghai University of Traditional Chinese Medicine Affiliated Shuguang Hospital

The stage of achievement:
Mode of cooperation: JointVentureandCooperation Outcome Information:
Countries/regions: China Intellectual property rights: Invention patent, others
Introduction: Click to view
Hyperlipidemia, hypertension, and coronary heart disease are the underlying diseases of chronic heart failure. Based on the traditional Chinese medicine (TCM) theory of 'preventing disease before it occurs,' our team has established a comprehensive TCM and pharmaceutical prevention and treatment plan for the entire process of chronic heart failure, with significant clinical efficacy. We have also elucidated some of its mechanisms of action. Over the more than fifty years of team inheritance and innovation, the following innovative contents have been formed: Innovation Content One: Relying on the Cardiovascular Famous Doctor Inheritance Studio and the Cardiovascular TCM Characteristic Diagnosis and Treatment Information Database, we have established a TCM chronic heart failure auxiliary diagnosis decision support system and a chronic disease information management application platform. This has led to the formation of theories and treatment principles for staging prevention and treatment of chronic heart failure in TCM. Our team has developed a clinical TCM chronic heart failure auxiliary diagnosis decision support system and a chronic disease information management application platform. Combined with our hospital's heart failure center, The objective collection of information for patients with chronic heart failure was completed through the integration of four diagnostic devices. Based on the basic data set of traditional Chinese medicine electronic medical records, the system's interoperability was standardized; on the basis of integrating clinical big data, it provided full process data for patients with chronic heart failure. After statistical analysis and mining, the academic thoughts of famous old TCM physicians such as Zhang Boyu, Yan Shiyun, and Hu Wanying were inherited, forming a theory and treatment principles for staging prevention and treatment of chronic heart failure. Innovative content two: Constructing a comprehensive TCM strategy for the etiological treatment of heart failure to reduce the occurrence and development of chronic heart failure. Clinical efficacy and mechanism of TCM in preventing and treating hyperlipidemia: Based on the theory that 'there is also compatibility between Chinese and Western medicines,' a lipid-lowering formula was created to reduce toxicity and enhance efficacy, combining Chinese and Western medicine to lower blood lipid levels and reduce the occurrence and development of heart failure. It effectively improves TC and LDL-C levels, The mechanism lies in the fact that lipid-lowering agents can effectively inhibit the expression of CYP3A4, BCRP, and OATP1B1, and in the liver microsomal environment, they can significantly slow down the metabolism rate of atorvastatin. Clinical efficacy and mechanisms of traditional Chinese medicine (TCM) in the prevention and treatment of hypertension: Based on the pathogenesis of 'yin deficiency and yang hyperactivity' in hypertension, the hospital preparation Qianyang Mixture protects target organs and reduces the incidence of heart failure. For hypertensive patients with kidney damage due to yang qi deficiency syndrome, a blood pressure-lowering formula has been established to effectively treat renal hypertension, delay the progression of the disease, and reduce the incidence of heart failure. Clinical efficacy and mechanisms of TCM in the prevention and treatment of coronary heart disease: Based on the academic thoughts of Professor Zhang Boyu, a renowned national expert in TCM, combined with the theory that the essence of coronary heart disease is fundamentally deficiency with manifestations of excess, including insufficiency of yin, yang, qi, and blood, as well as excesses such as stasis, turbidity, and qi stagnation, a TCM staging treatment plan for coronary heart disease has been proposed. While actively using coronary stent treatment, the Wen Yang Huo Xue prescription is used to reduce the restenosis rate/mortality rate after stent implantation in patients. The mechanism is mainly related to antioxidant stress and inflammatory response. Innovative content three: Based on the staging theory of chronic heart failure treatment, a series of deer antler prescriptions were created and their important mechanisms elucidated. According to the 'treating the heart from the kidney' staging theory for chronic heart failure, targeting the pathogenesis of early deficiency of both kidney yin and yang, middle stage kidney deficiency with blood stasis, and late stage heart and kidney yang deficiency in three stages of chronic heart failure, the treatment is given throughout the entire disease process. It reveals that the deer antler series prescriptions are mainly aimed at early left ventricular adverse remodeling; middle stage focuses on improving myocardial energy metabolism reconstruction; and late stage inhibits cardiac interstitial fibrosis. This project has been carried out in Shanghai, The use of civilized vocabulary is as follows: In Beijing and other tertiary hospitals, as well as in communities, the promotion of the use of deer red prescription and deer astragalus prescription has been carried out. The deer red prescription has already applied for a patent and has successfully been transferred to Jiangxi Jimin Xukei Pharmaceutical Co., Ltd., achieving good social and economic benefits. This project has trained 9 doctoral students and 35 master's degree candidates, published 155 related academic papers, including 12 SCI-indexed articles, and 62 representative papers have been cited 321 times through third-party citation inquiries. As an appropriate technology, it has organized 15 national and municipal continuing education classes, promoting more than 3000 people with a profound impact.
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