This project belongs to the field of integrated traditional Chinese and Western medicine neurology. The lack of objective quantification in the evaluation system for the efficacy of integrated treatment of neuro内科 diseases has limited the promotion and application of integrated methods in neurological disorders. Neurological diseases often accompany abnormal physical activity, which can serve as an objective indicator for assessing the severity of the disease and evaluating clinical efficacy. At the same time, research on the occurrence and diagnosis of neurological diseases also requires corresponding animal models to reflect the characteristics and severity of the disease and can be used as objective evaluation indicators for clinical drug intervention. This project aims to combine clinical and basic evaluation methods, with innovative objective quantitative evaluation indicators for integrated diagnosis and treatment of neuro内科 diseases as a breakthrough, to develop a clinical evaluation system guided by the theory of combining syndrome differentiation and disease identification. Over the past decade, it has achieved several important innovations: 1. In clinical practice, it has provided an internationally recognized objective quantitative evaluation method for assessing the efficacy of integrated traditional Chinese and Western medicine approaches in treating neurological diseases. By using accelerometer recorders to capture raw data from different body parts, we have improved and developed quantitative evaluation parameters suitable for various disease characteristics. We have created new models for evaluating the efficacy of treatments targeting stroke, Parkinson's disease (PD) motor and non-motor symptoms, PD sleep disorders, motor neuron diseases, Alzheimer's disease (AD), dementia with psychiatric behavioral abnormalities, restless legs syndrome, and neurogenic pruritus. The proposed 'Different diseases, different syndromes, different behavioral parameters; similar behavior parameters may exist for the same syndrome in different diseases' provides a behavioral basis that combines disease patterns with objective quantitative parameters, offering a new model for evaluating the efficacy of integrated traditional Chinese and Western medicine treatments in neurology. This technology has been developed at the Oregon Research Institute in the United States. The application and promotion by medical institutions such as Harvard University School of Medicine in the United States, Affiliated Hospital of Tokyo University in Japan, Acupuncture College of Kansai Medical University in Japan, University of Toulouse in France, Medical School of Graz University in Austria, and the Medical Academy of Isfahan University in Iran, as well as ten other medical institutions in Shanghai, Guangdong, Ningxia, etc., have achieved significant social benefits. 2. It has provided reliable animal models for the diagnosis and treatment of neuro内科 diseases, especially neurodegenerative diseases, through the integration of traditional Chinese and Western medicine. The study explored the regulatory mechanisms of lncRNA and miRNA on the occurrence of neurodegenerative diseases (Parkinson's disease and Alzheimer's disease) and the epigenetic modification regulation of stem cell therapy, and provided a relatively reliable animal model for the efficacy evaluation of traditional Chinese medicine that nourishes the liver and kidney in treating neurodegenerative diseases; internationally, it established an ovarian failure model induced by cyclophosphamide chemotherapy damage in mice. The study explored the therapeutic effects of stem cells combined with microRNAs, suggesting that a heart-regulating formula that nourishes liver and kidney may improve premature aging to some extent and prevent or delay Alzheimer's disease and Parkinson's disease. The detailed description of the miRNA regulatory mechanisms for maintaining pluripotency in vitro and directing differentiation of iPS cells into human sperm-like cells and chondrocytes was provided. It was explained that lncRNAs play a regulatory role in the development and maintenance of mammals, especially in the occurrence of Alzheimer's disease. Changes in this target can serve as a biological marker for the slowdown of Alzheimer's disease progression by the nourishing liver and kidney formula. Dr. Fuping Zhang from the University of Turku in Finland has given high praise to the research achievements on neurodegenerative diseases. During the project research period, 60 papers were published, including 22 SCI-indexed articles with a total impact factor of 67 points. Cited positively by others 232 times, with SCI citations of 185; reported at international and domestic academic conferences 11 times; trained 7 master's degree students. This project reflects the characteristics and advantages of combining syndrome differentiation and disease treatment in traditional Chinese medicine (TCM), objectively quantifying the efficacy of TCM in treating major neurological diseases, and is a beneficial practice of translational medicine in the participation of TCM in the prevention and treatment of chronic nervous system diseases.