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DevelopmentandApplicationofAcupunctureTreatmentforOveractiveBladderBasedontheRelationshipbetweenAcupointsandZangFuOrgans

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Registration number:G20251425

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Key words: Acupuncture meridian-visceral correlation theory appropriate technology

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Publisher:管理人员

Release time:2025-08-09 09:21:49.0

  • Essential information
Name of achievement: DevelopmentandApplicationofAcupunctureTreatmentforOveractiveBladderBasedontheRelationshipbetweenAcupointsandZangFuOrgans
Result registration number: G20251425 Subject classification:
Green classification: Item keywords: Acupuncture   meridian-visceral correlation theory   appropriate technology    
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Shanghai University of Traditional Chinese Medicine

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Mode of cooperation: Outcome Information:
Countries/regions: Shanghai Intellectual property rights: Utility model patent
Introduction: Click to view
Overactive Bladder (hereinafter referred to as 'OAB') includes diseases such as urethral syndrome, urge incontinence, and unstable bladder (according to the '2007 Edition of Chinese Urological Diseases Diagnosis and Treatment Guidelines'), which are common and frequently occurring. Due to its complex pathogenesis, clinical first-line drug treatments have not been satisfactory. Acupuncture therapy has gradually become an important choice for treating OAB. However, there are bottlenecks such as inconsistent treatment plans, unclear mechanisms, and difficulties in promotion. This project, guided by the theory of acupoint-visceral correlation, has carried out research and promotion on the selection of effective acupoints for OAB treatment, determination of superior methods, and organization and evaluation of suitable acupuncture techniques for over a decade, achieving a series of innovative results: 1. It was the first to screen and determine specific acupoints for OAB treatment with acupuncture. Through multicenter, Randomized controlled clinical studies, starting with the key issue of acupoint specificity, have conducted comparative research on the therapeutic effects of specific points of the Bladder Meridian, other meridian points, and combination of points from the same meridian in treating OAB. This has established an effective acupoint combination mainly based on points from the Bladder Meridian, Kidney Meridian, and Ren Meridian, providing a scientific basis for optimizing acupoint selection. 2. Establish an efficient method of acupuncture treatment for OAB. Through multicenter, randomized controlled clinical studies, the efficacy of different acupuncture methods and drug treatments for OAB was evaluated, establishing an efficient method of electroacupuncture combined with manual acupuncture for the treatment of OAB. 3. Pioneer the establishment of standardized protocols and appropriate techniques for acupuncture treatment of OAB. Through clinical research, integrating the research results of effective acupoints and effective treatment methods, a standardized protocol for acupuncture treatment of OAB was established. It also summarized to form 'Techniques for Electroacupuncture Combined with Manual Acupuncture Treatment of Female Urethral Syndrome' and 'Characteristic Techniques for Electroacupuncture Combined with Manual Acupuncture Treatment of Urge Incontinence'. Two national-level and two bureau-level acupuncture suitable technologies were completed. The design and research content of the relevant suitable technologies have been included in the National 'Guidelines for Clinical Diagnosis and Treatment Technology Research in Traditional Chinese Medicine'. 4. Achievements in the study of the mechanism of acupuncture treatment effects on Overactive Bladder (OAB) were made. A rat model of unstable bladder was established to compare urinary dynamics indicators such as bladder capacity at different time points after acupuncture, as well as immunohistochemistry of bladder smooth muscle. It was found and confirmed that acupuncture relaxes the detrusor muscle through neurogenic pathways involving nitrogenous neurotransmitters and cholinergic receptors; it also confirms that acupuncture regulates the instability of the detrusor muscle by modulating the excitability of bladder pacemaker cells and their intercellular information communication, which are myogenic pathways. During the project research period, a total of 54 papers were published, including 11 SCI-indexed articles with 287 citations, 3 authorized patents, 7 monographs, and 8 doctoral students trained. There are 48 master's degree students. At the same time, the project team has carried out the promotion of acupuncture treatment for overactive bladder through various forms such as training classes, continuing education, and lectures. They have trained and built a backbone team for promotion, with one person selected as an expert consultant on appropriate technology promotion by the Shanghai Health Bureau. The team has systematically trained more than 3,000 doctors from over 700 units in 15 provinces and cities; they have constructed an online platform for the promotion of appropriate technology, established three western cooperative bases for TCM appropriate technologies in Xinjiang, Gansu, and Yunnan; their unit has been developed into a specialty clinic for acupuncture urinary disorders in Shanghai and a secondary laboratory for acupuncture urology, forming an incubation and training base for the research and promotion of appropriate technologies. The project has explored and established an effective path for the organization, development, transformation, and application of TCM appropriate technologies, promoting their discipline to become a national key (cultivation) discipline, a Shanghai medical center, and a Shanghai key discipline. Significant social benefits have been generated.
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