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ConstructionandApplicationofTraditionalChineseMedicinePrescriptionSyndromeResearchandNewDrugDevelopmentDecisionServicePlatform

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Registration number:G20251424

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Key words: Prescription Science Traditional Chinese Medicine

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Publisher:管理人员

Release time:2025-08-09 09:21:48.0

  • Essential information
Name of achievement: ConstructionandApplicationofTraditionalChineseMedicinePrescriptionSyndromeResearchandNewDrugDevelopmentDecisionServicePlatform
Result registration number: G20251424 Subject classification:
Green classification: Item keywords: Prescription Science  Traditional Chinese Medicine      
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Shanghai University of Traditional Chinese Medicine

The stage of achievement:
Mode of cooperation: Outcome Information:
Countries/regions: Shanghai Intellectual property rights: Invention patent, computer software copyright.
Introduction: Click to view
The project falls within the research scope of TCM Information Engineering in the field of traditional Chinese medicine. Over the past decade, there have been no fewer than a dozen TCM prescription databases developed nationwide, whose knowledge systems are basically derived from the 'Comprehensive Dictionary of TCM Formulas', and they belong to general retrieval-type databases. Or they merely focus on screening information about the compounds of traditional Chinese medicine and their chemical structures, biological activities, etc., without a data processing platform that can fully reflect the academic principles of TCM such as 'theory, method, prescription, and drug, consistent throughout'. Since 2005, with the support of the Shanghai Municipal Science and Technology Commission and the Shanghai Municipal Education Commission, based on Zhu Bangxian's interpretation of the principle of 'relative prescriptions and syndromes', the project team has used database technology, Web technology, ontology methods, artificial intelligence, etc., to construct the 'TCM Prescription and Syndrome Research and New Drug Development Decision-Making Service Platform' (referred to as the 'Platform'). The platform has achieved structured storage of traditional Chinese medicine literature from various dynasties based on the hierarchical relationships of elements such as prescriptions, diseases and syndromes, etiology and pathogenesis, treatment principles and methods, drugs, medical cases, and medical theories. This allows for the association, clustering, and in-depth mining of element data. Through the discovery of knowledge rules, it supports users to make scientific decisions in scientific research, teaching, and clinical work related to traditional Chinese medicine. The platform has gathered a collection of 120,000 prescriptions, over 8,900 species of herbal medicines, more than 1,800 traditional Chinese disease names, over 378,000 entries of diseases and syndromes, over 16,000 entries of treatment principles and methods, more than 25,000 verified cases by famous doctors, and dual diagnosis data from the first pages of over 2.5 million hospital records from over a hundred hospitals across the country. In the second phase of construction, new core literature from various clinical disciplines throughout history (110 types), standard preparations of proprietary Chinese medicines (over 4,300 items), and a traditional Chinese medicine search engine (including GB95, The database cluster, including GB97 and self-compiled TCM-BZ, etc., features multi-axial, multi-channel, and multi-level data association, composite filtering, and other retrieval and statistical functions. The invention and innovation points of the project are mainly reflected in: 1. Explaining the principle of 'relative prescription and syndrome': Clarifying the connotation of the principle of relative prescription and syndrome refers to the high specificity or relevance between the drug composition and compatibility of a prescription and the basic pathogenesis inherent in its main treatment diseases, and implementing it throughout the platform construction process. 2. Establishing a consistent treatment model for syndrome elements based on theory, method, prescription, and medicine: Using the ID-Portal modular framework and ontology technologies, constructing an interactive relationship between 'disease-syndrome (syndrome)-theory-method-prescription-medicine' elements and data hierarchical structured storage, providing a comprehensive solution for 'theory, method, prescription, medicine, The consistent documentation processing lays the foundation for information technology. 3. Create an automatic recognition and annotation system for ancient literature: By using semantic Web technology to parse GB95, GB97, and subject word lists, construct self-made standards for informatization and structuring of traditional Chinese medicine (TCM), realize computer recognition and annotation of TCM literature, and become an important support for China to gain discourse power and lead in compiling WHO ICTM. 4. Create an automatic batch processing system for specialized disease literature data in TCM: With the support of the system, complete the automatic generation and construction of databases for liver diseases, kidney diseases, coronary heart disease, and tumors in TCM, providing basic literature for specialized disease research. 5. Through the practice of building a 'prescription syndrome relative' principle intervention system based on modern major disease pathological processes for national major new drug creation projects, Discover and form original technical principles, technical solutions, process handling, and screening result correction for the selection of traditional Chinese medicine prescriptions to intervene in modern major diseases. Since the launch of services on January 1, 2009 (China Traditional Chinese Medicine Network, www.med-ch.com), there are now 418 registered members with 12,390 IP addresses, and the website has received over 709,000 visits; the user distribution covers all provinces, cities, and regions of the country (including Hong Kong, Macao, and Taiwan) as well as 53 countries and international organizations such as the United States, the Netherlands, Germany, Czech Republic, Russia, Japan, Singapore, Australia, South Korea, WHO, ISO, etc.; it has provided services for major projects of the National Science and Technology Department, traditional medicine standards of WHO, and national standard revisions. It has published 34 papers with a total citation of 272 times, an average of 8 citations per paper; it has received 11 scientific research grants and 5 patent authorizations. Two scientific and technological awards; 12 graduate students trained.
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